The term “adrenal fatigue” is based on the assumption that your adrenal gland has the capacity to fatigue - but certain organs in your body are not so easily subverted. They work constantly and have a huge functional capacity - just like your heart or lungs. They’re responsible for producing, secreting and regulating specific hormones in your body, including cortisol. Q: Is it possible for your adrenal glands to be truly fatigued?Ī: The adrenal glands have a big job. Policyīut the problem with the term “adrenal fatigue,” which is not an officially recognized diagnosis, is that it has been used to describe a group of symptoms when nothing else can be used to explain it.Įndocrinologist Shirisha Avadhanula, MD, discusses the truth about adrenal fatigue and how a proper diagnosis and multidisciplinary care can lead to symptom relief. We do not endorse non-Cleveland Clinic products or services.

Advertising on our site helps support our mission. On the other hand, longitudinal studies monitoring the levels of vitamin D in patients with adrenal disorders or, conversely, the possible development of adrenal pathologies in subjects affected by impaired vitamin D levels would be able to elucidate this still unclear issue.Īdrenal gland disorders Adrenal insufficiency Adrenal tumors Cushing’s syndrome Hyperaldosteronism Vitamin D.Cleveland Clinic is a non-profit academic medical center. Evidence coming from cross-sectional clinical studies can hardly clarify what comes first between vitamin D unbalance and adrenal disease. We conclude that there is insufficient evidence proving a causal relationship between vitamin D levels and adrenal disorders. In this review, we provide an updated document, which tries to collect and discuss the limited evidence to be found in the literature about the relationship between vitamin D and adrenal disorders.

Adrenal gland disorders, which might be theoretically affected by vitamin D unbalance, include adrenal insufficiency, Cushing's syndrome, adrenocortical tumors and hyperaldosteronism. In this regard, a still little studied aspect concerns the involvement of vitamin D in adrenal gland disorders. An emerging branch of research is examining the linkage between Vitamin D and nonskeletal disorders, including endocrine diseases.

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